منابع مشابه
DFVF: database of fungal virulence factors
Fungal pathogens cause various diseases for plant and animal hosts. Despite the extensive impact of fungi on human health and life, the threats posed by emerging fungal pathogens are poorly understood. Specifically, there exist few fungal virulence gene databases, which prevent effective bioinformatics studies on fungal pathogens. Therefore, we constructed a comprehensive online database of kno...
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Fungal pathogens rely on the production of specific virulence factors during infection. Inhibiting such factors generally results in reduced fungal pathogenicity. Most studies in the past have focused on understanding the molecular mechanisms of fungal virulence factor expression during mono-culture, or during interaction with the host. However, a potentially important, second type of interacti...
متن کاملMetals in fungal virulence
Metals are essential for life, and they play a central role in the struggle between infecting microbes and their hosts. In fact, an important aspect of microbial pathogenesis is the 'nutritional immunity', in which metals are actively restricted (or, in an extended definition of the term, locally enriched) by the host to hinder microbial growth and virulence. Consequently, fungi have evolved of...
متن کاملVFDB: a reference database for bacterial virulence factors
Bacterial pathogens continue to impose a major threat to public health worldwide in the 21st century. Intensified studies on bacterial pathogenesis have greatly expanded our knowledge about the mechanisms of the disease processes at the molecular level over the last decades. To facilitate future research, it becomes necessary to form a database collectively presenting the virulence factors (VFs...
متن کاملDual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors
The Drosophila immune system discriminates between various types of infections and activates appropriate signal transduction pathways to combat the invading microorganisms. The Toll pathway is required for the host response against fungal and most Gram-positive bacterial infections. The sensing of Gram-positive bacteria is mediated by the pattern recognition receptors PGRP-SA and GNBP1 that coo...
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ژورنال
عنوان ژورنال: Database
سال: 2012
ISSN: 1758-0463
DOI: 10.1093/database/bas032